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Immunogen sequence: KCQECRLRK CRQAGMREEC VLSEEQIRLK KLKRQEEEQA HATSLPPRAS SPPQILPQLS PEQLGMIEKL VAAQQQCNRR SFSDRLRVTP WPMAPDPHSR EARQQRFAHF TELAIVSVQE IVDFAKQLPG FLQLSREDQI ALLKTSAIEV MLLETSRRYN PGSESITFLK DFSYNREDFA KAGLQVEFIN PIFEFSRAMN ELQLNDAEFA LLIAISIFSA DRPNVQDQLQ VERLQHTYVE ALHAYVSIHH PHDRLMFPRM LMKLVSLRTL SSVHSEQVFA LRLQDKKLPP LLSEIWDVHE (104-402 aa encoded by BC041172)
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: liver X nuclear receptor alpha variant 1; Liver X receptor alpha; LXRb; NER; NERI; NR1H2; nuclear orphan receptor LXR-alpha; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; Oxysterols receptor LXR-alpha; RLD-1
基因别名: LXR-a; LXRA; LXRalpha; NR1H3; RLD-1
UniProt ID: (Human) Q13133
Entrez Gene ID: (Human) 10062, (Rat) 58852