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Immunogen sequence: MCPVDKAHR NQCQACRLKK CLQAGMNQDA VQNERQPRST AQVHLDSMES NTESRPESLV APPAPAGRSP RGPTPMSAAR ALGHHFMASL ITAETCAKLE PEDADENIDV TSNDPEFPSS PYSSSSPCGL DSIHETSARL LFMAVKWAKN LPVFSSLPFR DQVILLEEAW SELFLLGAIQ WSLPLDSCPL LAPPEASAAG GAQGRLTLAS METRVLQETI SRFRALAVDP TEFACMKALV LFKPETRGLK DPEHVEALQD QSQVMLSQHS KAHHPSQPVR FGKLLLLLPS LRFITAERIE LLFFRKTIGN TPMEKLLCDM FKN (1-322 aa encoded by BC041421)
NR2E3, a NR2 Hepatocyte NF4-Like Receptor, has been suggested to affect cone cell proliferation in eye development. It has been shown to have a role in determining photoreceptor phenotype during human retinogenesis. In RD7 mice, a deletion in NR2E3 results in hereditary retinal dysplasia and degeneration. A homozygous missense mutation in NR2E3 has been linked to retinitis pigmentosa in Crypto-Jews of Belmonte. Two alternatively spliced isoforms have been documented. NR2E3 is expressed in the retina. ESTs have been isolated from cancerous human lung, colon, and ovary, and from normal human eye.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MGC138414; MGC138416; Nuclear receptor subfamily 2 group E member 3; nuclear receptor subfamily 2, group E, member 3; Photoreceptor-specific nuclear receptor; Retina-specific nuclear receptor; retinal degeneration 7; RP11-295F4.5; taR-5
基因别名: A930035N01Rik; ESCS; NR2E3; PNR; rd7; RNR; RP37
UniProt ID: (Human) Q9Y5X4, (Mouse) Q9QXZ7
Entrez Gene ID: (Human) 10002, (Pig) 102159757, (Rat) 100365683, (Mouse) 23958
分子生物学功能: C4 zinc finger nuclear receptor