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NR3C2 Antibody (PA5-79761) in WB
Western blot analysis of NR3C2 in, Lane 1: human Hela whole cell lysates, Lane 2: human 293T whole cell lysates, Lane 3: human LNCAP whole cell lysates, Lane 4: human MCF-7 whole cell lysates, Lane 5: rat NRK whole cell lysates, Lane 6: mouse NIH/3T3 whole cell lysates. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 µg of sample under reducing conditions. After Electrophoresis, proteins were transferred to a nitrocellulose memb... View More
产品信息
PA5-79761
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human NR3C2 (950-984aa HALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746876
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. These compounds exert their effect through their interaction with the mineralocorticoid receptor (MR) and that complex's subsequent association with DNA. Given the function of mineralocorticoids, it is not surprising to find that the kidney is a primary target organ for mineralocorticoids and that this organ has been shown to contain MR. The corresponding gene for the mineralocorticoid receptor is NR3C2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: aldosterone receptor; Mineralocorticoid receptor; Mineralocorticoid receptor (aldosterone receptor); mineralocorticoid receptor 1; mineralocorticoid receptor 2; mineralocorticoid receptor delta; MR; Nuclear receptor subfamily 3 group C member 2; nuclear receptor subfamily 3, group C, member 2 variant 3
基因别名: MCR; MLR; MR; NR3C2; NR3C2VIT
UniProt ID: (Human) P08235, (Rat) P22199
Entrez Gene ID: (Human) 4306, (Mouse) 110784, (Rat) 25672
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
steroid binding
protein binding
zinc ion binding
sequence-specific DNA binding
DNA binding
double-stranded DNA binding
lipid binding
mineralocorticoid receptor activity
hormone binding
protein homodimerization activity
metal ion binding
protein heterodimerization activity
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cellular sodium ion homeostasis
excretion
mineralocorticoid receptor signaling pathway
regulation of cell proliferation
steroid hormone mediated signaling pathway
transcription initiation from RNA polymerase II promoter
signal transduction
