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NR3C2/Mineralocorticoid receptor Antibody (BS-1850R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Mouse brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with Mineralocorticoid receptor Polyclonal Antibody, Unconjugated (bs-1850R) at 1:400 overnight at 4°C, followed by secondary and DAB stain... View More
产品信息
BS-1850R
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human Mineralocorticoid receptor, amino acids 601-700.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. These compounds exert their effect through their interaction with the mineralocorticoid receptor (MR) and that complex's subsequent association with DNA. Given the function of mineralocorticoids, it is not surprising to find that the kidney is a primary target organ for mineralocorticoids and that this organ has been shown to contain MR. The corresponding gene for the mineralocorticoid receptor is NR3C2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aldosterone receptor; Mineralocorticoid receptor; Mineralocorticoid receptor (aldosterone receptor); mineralocorticoid receptor 1; mineralocorticoid receptor 2; mineralocorticoid receptor delta; MR; Nuclear receptor subfamily 3 group C member 2; nuclear receptor subfamily 3, group C, member 2 variant 3
基因别名: MCR; MLR; MR; NR3C2; NR3C2VIT
UniProt ID: (Human) P08235, (Rat) P22199
Entrez Gene ID: (Human) 4306, (Dog) 475461, (Mouse) 110784, (Rat) 25672
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
steroid binding
protein binding
zinc ion binding
sequence-specific DNA binding
DNA binding
double-stranded DNA binding
lipid binding
mineralocorticoid receptor activity
hormone binding
protein homodimerization activity
metal ion binding
protein heterodimerization activity
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cellular sodium ion homeostasis
excretion
mineralocorticoid receptor signaling pathway
regulation of cell proliferation
steroid hormone mediated signaling pathway
transcription initiation from RNA polymerase II promoter
signal transduction
