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产品信息
PA5-41485
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the C-terminal of human NRF1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2607684
产品详细信息
Peptide sequence: IVLSGETAAA VGALTGVQDA NGLFMADRAG RKWILTDKAT GLVQIPVSMY
Sequence homology: Human: 100%; Rat: 91%
靶标信息
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha palindromic-binding protein; Alpha-pal; EWG; NRF-1; Nuclear respiratory factor 1
基因别名: ALPHA-PAL; NRF1
UniProt ID: (Human) Q16656
Entrez Gene ID: (Human) 4899
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
protein homodimerization activity
DNA-binding transcription factor
response to hypoxia
generation of precursor metabolites and energy
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
mitochondrion organization
organ regeneration
response to estradiol
response to lipopolysaccharide
positive regulation of transcription from RNA polymerase II promoter
response to folic acid
response to electrical stimulus
