Product References
The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons.
Molecular psychiatry
Wang H,Cui W,Chen W,Liu F,Dong Z,Xing G,Luo B,Gao N,Zou WJ,Zhao K,Zhang H,Ren X,Yu Z,Robinson HL,Liu Z,Xiong WC,Mei L
MA5-12896 was used in Western Blot to demonstrate a critical role of NRG1-ErbB4 signaling in regulating depression-like behaviors and identify an unexpected mechanism by which the LDTg-VTA circuit regulates the activity of DA neurons.
Wed Mar 01 00:00:00 UTC 2023
The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons.
Molecular psychiatry
Wang H,Cui W,Chen W,Liu F,Dong Z,Xing G,Luo B,Gao N,Zou WJ,Zhao K,Zhang H,Ren X,Yu Z,Robinson HL,Liu Z,Xiong WC,Mei L
MA5-12896 was used in Western Blot to demonstrate a critical role of NRG1-ErbB4 signaling in regulating depression-like behaviors and identify an unexpected mechanism by which the LDTg-VTA circuit regulates the activity of DA neurons.
Wed Mar 01 00:00:00 UTC 2023
Neuregulin 1 enhances cell adhesion molecule L1 like expression levels and promotes malignancy in human glioma.
Oncology letters
Lin WW,Ou GY,Lin JZ,Yi SJ,Yao WC,Pan HC,Zhao WJ
MA5-12896 was used in Western Blotting to indicate that NRG1 can regulate CHL1 protein expression levels in gliomas, that it is correlated with malignancy, and that NRG1 may contribute to malignancy by upregulating CHL1 protein expression levels in glioma/glioblastoma cells.
Wed Jul 01 00:00:00 UTC 2020
Nedd4l downregulation of NRG1 in the mPFC induces depression-like behaviour in CSDS mice.
Translational psychiatry
Xu J,Guo C,Liu Y,Wu G,Ke D,Wang Q,Mao J,Wang JZ,Liu R,Wang X
MA5-12896 was used in Immunoprecipitation to show Nedd4l-mediated downregulation of NRG1 acts as a critical role in depression-like phenotypes of mice in CSDS.
Thu Jul 23 00:00:00 UTC 2020
Nedd4l downregulation of NRG1 in the mPFC induces depression-like behaviour in CSDS mice.
Translational psychiatry
Xu J,Guo C,Liu Y,Wu G,Ke D,Wang Q,Mao J,Wang JZ,Liu R,Wang X
MA5-12896 was used in Immunoprecipitation to show Nedd4l-mediated downregulation of NRG1 acts as a critical role in depression-like phenotypes of mice in CSDS.
Thu Jul 23 00:00:00 UTC 2020
Nedd4l downregulation of NRG1 in the mPFC induces depression-like behaviour in CSDS mice.
Translational psychiatry
Xu J,Guo C,Liu Y,Wu G,Ke D,Wang Q,Mao J,Wang JZ,Liu R,Wang X
MA5-12896 was used in Immunoprecipitation to show Nedd4l-mediated downregulation of NRG1 acts as a critical role in depression-like phenotypes of mice in CSDS.
Thu Jul 23 00:00:00 UTC 2020
Nedd4l downregulation of NRG1 in the mPFC induces depression-like behaviour in CSDS mice.
Translational psychiatry
Xu J,Guo C,Liu Y,Wu G,Ke D,Wang Q,Mao J,Wang JZ,Liu R,Wang X
MA5-12896 was used in Immunoprecipitation to show Nedd4l-mediated downregulation of NRG1 acts as a critical role in depression-like phenotypes of mice in CSDS.
Thu Jul 23 00:00:00 UTC 2020
Erbb4 Is Required for Cerebellar Developmentand Malignant Phenotype of Medulloblastoma.
Cancers
Aldaregia J,Errarte P,Olazagoitia-Garmendia A,Gimeno M,Uriz JJ,Gershon TR,Garcia I,Matheu A
MA5-12896 was used in Immunohistochemistry-immunofluorescence to characterise the role of ERBB4 during cerebellum development and medulloblastoma progression paying particular interests to its role in CGNPs and medulloblastoma stem cells (MBSCs).
Fri Apr 17 00:00:00 UTC 2020
A novel role for cilia-dependent sonic hedgehog signaling during submandibular gland development.
Developmental dynamics : an official publication of the American Association of Anatomists
Elliott KH,Millington G,Brugmann SA
Published figure using NRG1 monoclonal antibody (Product # MA5-12896) in Immunocytochemistry
Fri Jun 01 00:00:00 UTC 2018
Differential changes in Neuregulin-1 signaling in major brain regions in a lipopolysaccharide-induced neuroinflammation mouse model.
Molecular medicine reports
Yang Z,Jiang Q,Chen SX,Hu CL,Shen HF,Huang PZ,Xu JP,Mei JP,Zhang BP,Zhao WJ
MA5-12896 was used in western blot to study the alterations of brain Neuregulin-1 signaling during neuroinflammation
Fri Jul 01 00:00:00 UTC 2016
Expression and Localization of Neuregulin-1 (Nrg1) and ErbB2/ErbB4 Receptors in Main Endocrine Organs of the Rhesus Monkey.
International journal of endocrinology and metabolism
Zhao WJ
MA5-12896 was used in immunohistochemistry to study the expression of neuregulin-1 and its receptors in various Rhesus monkey endocrine tissues
Wed Dec 18 00:00:00 UTC 2013
Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy.
American journal of physiology. Heart and circulatory physiology
Lemmens K,Doggen K,De Keulenaer GW
MA5-12896 was used in Western Blotting to study the activity and function of the neuregulin/ErbB system in pregnancy.
Tue Mar 01 00:00:00 UTC 2011
Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury.
The Journal of biological chemistry
Finigan JH,Faress JA,Wilkinson E,Mishra RS,Nethery DE,Wyler D,Shatat M,Ware LB,Matthay MA,Mason R,Silver RF,Kern JA
MA5-12896 was used in western blot to study the role of neuregulin-1 and HER2 in regulating pulmonary epithelial permeability and acute lung injury
Fri Mar 25 00:00:00 UTC 2011
Metalloproteinase-dependent cleavage of neuregulin and autocrine stimulation of vascular endothelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kalinowski A,Plowes NJ,Huang Q,Berdejo-Izquierdo C,Russell RR,Russell KS
MA5-12896 was used in Western blotting following immunoprecipitation to study the role of cytokine-activated metalloproteinase cleavage of neuregulin in the autocrine activation of endothelial cell signalling pathways.
Thu Jul 01 00:00:00 UTC 2010
Phenotypic characterization of transgenic mice overexpressing neuregulin-1.
PloS one
Kato T,Kasai A,Mizuno M,Fengyi L,Shintani N,Maeda S,Yokoyama M,Ozaki M,Nawa H
MA5-12896 was used in western blot to study the cognitive and behavioural phenotype of transgenic mice overexpressing neuregulin-1
Thu Dec 09 00:00:00 UTC 2010
Neuregulin-1 signaling in brain endothelial cells.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Lok J,Sardi SP,Guo S,Besancon E,Ha DM,Rosell A,Kim WJ,Corfas G,Lo EH
MA5-12896 was used in western blot to study neuregulin-1 signaling in brain microvascular endothelial cells
Thu Jan 01 00:00:00 UTC 2009
Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure.
Journal of molecular and cellular cardiology
Doggen K,Ray L,Mathieu M,Mc Entee K,Lemmens K,De Keulenaer GW
MA5-12896 was used in western blot to investigate the involvement of ventricular ErbB2 and ErbB4 receptors in the development of pacing-induced heart failure
Thu Jan 01 00:00:00 UTC 2009
Peripheral neuropathy in the twitcher mouse: accumulation of extracellular matrix in the endoneurium and aberrant expression of ion channels.
Acta neuropathologica
Kagitani-Shimono K,Mohri I,Yagi T,Taniike M,Suzuki K
MA5-12896 was used in immunohistochemistry to investigate the extracellular and protein abnormalities in peripheral neuropathy
Thu May 01 00:00:00 UTC 2008
Constitutive neuregulin-1/ErbB signaling contributes to human vestibular schwannoma proliferation.
Glia
Hansen MR,Roehm PC,Chatterjee P,Green SH
MA5-12896 was used in immunoprecipitation and western blot to study the role of constitutive neuregulin-1/ErbB signaling in human vestibular schwannoma proliferation
Sat Apr 15 00:00:00 UTC 2006
Localization of neuregulin-1alpha (heregulin-alpha) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brain.
Brain research bulletin
Bernstein HG,Lendeckel U,Bertram I,Bukowska A,Kanakis D,Dobrowolny H,Stauch R,Krell D,Mawrin C,Budinger E,Keilhoff G,Bogerts B
MA5-12896 was used in immunohistochemistry to study the localization of neuregulin-1alpha and ErbB-4 tyrosine kinase in developing and adult human brain
Mon May 15 00:00:00 UTC 2006
Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk.
The Journal of biological chemistry
Lemmens K,Segers VF,Demolder M,De Keulenaer GW
MA5-12896 was used in immunoprecipitation to study the role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk
Fri Jul 14 00:00:00 UTC 2006
NRG1 gene rearrangements in clinical breast cancer: identification of an adjacent novel amplicon associated with poor prognosis.
Oncogene
Prentice LM,Shadeo A,Lestou VS,Miller MA,deLeeuw RJ,Makretsov N,Turbin D,Brown LA,Macpherson N,Yorida E,Cheang MC,Bentley J,Chia S,Nielsen TO,Gilks CB,Lam W,Huntsman DG
MA5-12896 was used in immunohistochemistry to investigate the association of NRG1 gene rearrangements with poor prognosis in breast cancer treatment
Thu Nov 10 00:00:00 UTC 2005
Neuregulin-1 enhances survival of human astrocytic glioma cells.
Glia
Ritch PS,Carroll SL,Sontheimer H
MA5-12896 was used in western blot to study the mechanism by which neuregulin-1 promotes the survival of human astrocytoma cells
Mon Aug 15 00:00:00 UTC 2005
Paclitaxel and carboplatin as first-line chemotherapy combined with gefitinib (IRESSA) in patients with advanced breast cancer: a phase I/II study conducted by the Hellenic Cooperative Oncology Group.
Breast cancer research and treatment
Fountzilas G,Pectasides D,Kalogera-Fountzila A,Skarlos D,Kalofonos HP,Papadimitriou C,Bafaloukos D,Lambropoulos S,Papadopoulos S,Kourea H,Markopoulos C,Linardou H,Mavroudis D,Briasoulis E,Pavlidis N,Razis E,Kosmidis P,Gogas H
MA5-12896 was used in immunohistochemistry to investigate the efficacy of the combination of paclitaxel, carboplatin and gefitinib against advanced breast cancer
Fri Jul 01 00:00:00 UTC 2005
Expression of heregulin in human coronary atherosclerotic lesions.
Journal of vascular research
Panutsopulos D,Arvanitis DL,Tsatsanis C,Papalambros E,Sigala F,Spandidos DA
MA5-12896 was used in immunohistochemistry to study the expression of heregulin in human coronary atherosclerotic lesions
Mon Dec 05 00:00:00 UTC 2005
Back signaling by the Nrg-1 intracellular domain.
The Journal of cell biology
Bao J,Wolpowitz D,Role LW,Talmage DA
MA5-12896 was used in immunocytochemistry to study the bidirectional signaling of neuregulin-1 in neurones and the role of the intracellular domain in retrograde signaling
Mon Jun 23 00:00:00 UTC 2003
Reciprocal signaling between spiral ganglion neurons and Schwann cells involves neuregulin and neurotrophins.
Hearing research
Hansen MR,Vijapurkar U,Koland JG,Green SH
MA5-12896 was used in immunocytochemistry to study the role of neuregulin and neurotrophins in regulating spiral ganglion neuron-Schwann cell reciprocal signaling in the auditory nerve
Thu Nov 01 00:00:00 UTC 2001
