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IVNS1ABP is a protein coding gene involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro).; (Microbial infection) involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: aryl hydrocarbon receptor-associated 3; Aryl hydrocarbon receptor-associated protein 3; Influenza virus NS1A-binding protein; kelch-like family member 39; Kelch-like protein 39; NCX downstream gene 1; NS1-binding protein; NS1-BP
基因别名: ARA3; FLARA3; HSPC068; IVNS1ABP; KIAA0850; KLHL39; ND1; NS-1; NS1; NS1-BP; NS1BP
UniProt ID: (Human) Q9Y480
Entrez Gene ID: (Human) 10625
分子生物学功能:
scaffold/adaptor protein