Search Thermo Fisher Scientific
Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Monkey, Bovine, Dog, Pig (95%); Marmoset, Mouse, Rat (90%); Hamster (85%); Rabbit (80%).
For IHC(P), use proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Levocabastine-sensitive neurotensin receptor; Neurotensin receptor type 2; neurotensin receptor, type 2; NT-R-2; NT2 receptor
基因别名: NTR2; NTSR2
UniProt ID: (Human) O95665
Entrez Gene ID: (Human) 23620
分子生物学功能: G-protein coupled receptor