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产品信息
PA5-41311
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human NUCB2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2608253
产品详细信息
Peptide sequence: MMKEHERREY LKTLNEEKRK EEESKFEEMK KKHENHPKVN HPGSKDQLKE
Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 93%; Yeast: 91%
靶标信息
NUCB2 was initially identified as calcium-binding protein EF hand motif-containing protein that could bind with Necdin, a growth suppressor expressed primarily in postmitotic neurons. NUC2 is a secreted protein that is cleaved into three major peptide products, Nesfatin-1, Nesfatin-2, and Nesfatin-3, of which Nesfatin-1 has been found to cause the suppression of food intake in a leptin-independent manner. Other studies have suggested that NUCB2/Nesfatin-1 may also play roles in energy homeostasis and closely related neuroendocrine functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA-binding protein NEFA; Epididymis secretory protein Li 109; Gastric cancer antigen Zg4; nesfatin 1; nesfatin-1; Nucleobindin-2; Nucleobindin-2/Nesfatin-1; nucleobinding 2; prepronefastin; Prepronesfatin
基因别名: AI607786; Calnuc; HEL-S-109; NEFA; Nesfatin-1; NUCB2
UniProt ID: (Human) P80303, (Mouse) P81117
Entrez Gene ID: (Human) 4925, (Mouse) 53322
cellular calcium ion homeostasis
negative regulation of cAMP biosynthetic process
negative regulation of appetite
negative regulation of fat cell differentiation
positive regulation of fatty acid oxidation
negative regulation of insulin receptor signaling pathway
negative regulation of glucagon secretion
insulin metabolic process
positive regulation of testosterone secretion
