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NUDT15 Antibody (PA5-89643) in WB
Western blot analysis of NUDT15 in extracts of Rat spleen. Samples were incubated with NUDT15 Polyclonal antibody (Product # PA5-89643) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-89643
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human NUDT15 (NP_0607531)
偶联物
形式
Liquid
浓度
1.22 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805707
产品详细信息
Immunogen sequence: MTASAQPRGR RPGVGVGVVV TSCKHPRCVL LGKRKGSVGA GSFQLPGGHL EFGETWEECA QRETWEEAAL HLKNVHFASV VNSFIEKENY HYVTILMKGE VDVTHDSEPK NVEPEKNESW EWVPWEELPP LDQLFWGLRC LKEQGYDPFK EDLNHLVGYK GNHL; Positive Samples: Mouse spleen
靶标信息
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 7,8-dihydro-8-oxoguanine-triphosphatase NUDT15; 8-oxo-dGTPase NUDT15; mMTH2; MutT homolog 2; Nucleoside diphosphate-linked moiety X motif 15; Nucleoside diphosphate-linked to another moiety X hydrolase 15; Nucleotide triphosphate diphosphatase NUDT15; Nudix hydrolase 15; Nudix motif 15; nudix-type motif 15; probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15; RP11-90M2.1
基因别名: 6530403O17; A730068G11Rik; MTH2; Nudt15
UniProt ID: (Mouse) Q8BG93
Entrez Gene ID: (Rat) 290365, (Mouse) 214254
