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Application
FIGURE: 1 / 1
NUP107 Antibody (PA5-144678) in WB
Western blot analysis of NUP107 in different various lysates. Lane 1: Hela cell lysate (20 µg/Lane); Lane 2: 293T cell lysate (20 µg/Lane); Lane 3: HepG2 cell lysate (20 µg/Lane); Lane 4: Jurkat cell lysate (20 µg/Lane); Lane 5: PC-3M cell lysate (20 µg/Lane); Lane 6: A549 cell lysate (20 µg/Lane); Lane 7: MCF-7 cell lysate (20 µg/Lane); Lane 8: PC-12 cell lysate (20 µg/Lane); Lane 9: RAW264.7 cell lysate (20 µg/Lane)Lane 10: NIH/3T3 cell lysate (20 µg/Lane)Lane 11: Mouse testis tissue lysate (30 µg/Lane). Predicted band size: 106 kDa. Obs... View More
Product Details
PA5-144678
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human aa 626-925/925.
Conjugate
Unconjugated
Form
Liquid
Concentration
2 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3094103
Product Specific Information
Positive control: Hela cell lysate, 293T cell lysate, HepG2 cell lysate, Jurkat cell lysate, PC-3M cell lysate, A549 cell lysate, MCF-7 cell lysate, PC-12 cell lysate, RAW264.7 cell lysate, NIH/3T3 cell lysate, mouse testis tissue lysate.
Predicted band size: 106 kDa
Subcellular Location: Nucleus membrane, Nucleus, nuclear pore, Chromosome, centromere, kinetochore.
Target Information
The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP107 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP107 may be an important drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 107 kDa nucleoporin; nuclear pore complex; Nuclear pore complex protein Nup107; nucleoporin 107kDa; Nucleoporin Nup107; p105
Gene Aliases: AW541137; C76801; NPHS11; NUP107; NUP84
UniProt ID: (Human) P57740, (Mouse) Q8BH74
Entrez Gene ID: (Human) 57122, (Rat) 116555, (Mouse) 103468
posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
regulation of transcription, DNA-templated
mRNA export from nucleus
tRNA export from nucleus
protein import into nucleus
sister chromatid cohesion
mitotic nuclear envelope disassembly
regulation of glucose transport
viral process
protein sumoylation
viral transcription
gene silencing by RNA
nuclear pore complex assembly
intracellular transport of virus
regulation of cellular response to heat
protein transport
transmembrane transport
transport
mRNA transport
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