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Immunogen sequence: VHVALVLFE LKLLLKSSGQ RAQLLSHEPG DPPCLRRLNF VRLLMLYTRK FESTDPREAL QYFYFLRDEK DSQGENMFLR CVSELVIESR EFDMILGKLE NDGSRKPGVI DKFTSDTKPI INKVASVAEN KGLFEEAAKL YDLAKNADKV LELMNKLLSP VVPQISAPQS NKERLKNMAL SIAERYRAQG ISANKFVDST FYLLLDLITF FDEYHSGHID RAFDIIERLK LVPLNQESVE ERVAAFRNFS DEIRHNLSEV LLATMNILFT QFKRLKGTSP SSSSRPQRVI EDRDSQLRSQ ARTLITFAGM IPYRTSGDTN ARLVQMEVLM N (490-819 aa encoded by BC034346)
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 93 kDa nucleoporin; CBP-interacting protein 4; Nuclear pore complex protein Nup93; nucleoporin 93kDa; Nucleoporin Nup93
基因别名: 2410008G02Rik; Cip4; KIAA0095; NIC96; NPHS12; NUP93
UniProt ID: (Human) Q8N1F7, (Mouse) Q8BJ71, (Rat) Q66HC5
Entrez Gene ID: (Human) 9688, (Mouse) 71805, (Rat) 291874
分子生物学功能: transporter