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This product is diluted and in a ready-to-use formulation.
A recommended positive control tissue for this product is Lung adenocarcinoma, however positive controls are not limited to this tissue type.
Napsin 1 is an aspartic protease that is generally expressed in the lung, but also present in kidney and in metastatic carcinomas throughout the body. Napsin 1 processes surfactant protein B in healthy pulmonary and renal tissues, but is abnormally regulated when carcinogenesis occurs. Thus, many researchers have found napsin evaluation to be useful in identifying several cancers, and differentiating primary tumors from metastases. When combined with thyroid transcription factor analysis, napsin can be used as a specific biomarker for differentiation of carcinoma types. Napsin has also been associated with pulmonary alveolar proteinosis as well as in protein catabolism in renal tubules.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: asp 4; ASP4; Aspartyl protease 4; kidney-derived aspartic protease-like protein; Napsin-1; Napsin-A; pronapsin A; TA01/TA02
基因别名: KAP; Kdap; NAP1; NAPA; NAPSA; SNAPA
UniProt ID: (Human) O96009
Entrez Gene ID: (Human) 9476