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Neutrophil elastase Antibody (PA5-115648) in ICC/IF
Immunocytochemistry analysis of Neutrophil elastase in HepG2 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115648). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG... View More
产品信息
PA5-115648
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ELANE(Accession P08246), corresponding to amino acid residues A231-H267.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900283
产品详细信息
Antibody detects endogenous levels of total Neutrophil Elastase.
靶标信息
The neutrophil form of elastase is 218 amino acids long, with two asparagine-linked carbohydrate chains (see glycosylation). It is present in azurophil granules in the neutrophil cytoplasm. There appear to be two forms of neutrophil elastase, termed IIa and IIb.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bone marrow serine protease; ELA2A; Elastase; elastase 2, neutrophil; Elastase-2; Elastase2; granulocyte-derived elastase; HLE; Human leukocyte elastase; Leukocyte elastase; Medullasin; Neutrophil elastase; PMN elastase; polymorphonuclear elastase
基因别名: ELA2; ELANE; F430011M15Rik; GE; HLE; HNE; NE; PMN-E; SCN1
UniProt ID: (Human) P08246, (Mouse) Q3UP87
Entrez Gene ID: (Human) 1991, (Rat) 299606, (Mouse) 50701
negative regulation of transcription from RNA polymerase II promoter
response to yeast
acute inflammatory response to antigenic stimulus
proteolysis
cellular calcium ion homeostasis
phagocytosis
response to UV
extracellular matrix disassembly
protein catabolic process
response to lipopolysaccharide
defense response to bacterium
positive regulation of MAP kinase activity
negative regulation of growth of symbiont in host
negative regulation of chemokine biosynthetic process
negative regulation of interleukin-8 biosynthetic process
positive regulation of interleukin-8 biosynthetic process
positive regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
positive regulation of immune response
leukocyte migration
negative regulation of chemotaxis
neutrophil mediated killing of fungus
biological_process
defense response to fungus
transcription from RNA polymerase II promoter
