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Invitrogen
Neutrophil elastase Recombinant Rabbit Monoclonal Antibody (2H12)
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Neutrophil elastase Antibody (MA5-49834) in IHC (P)
Immunohistochemistry analysis with a Neutrophil elastase monoclonal antibody (Product # MA5-49834) using a dilution of 1:100 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 min at RT. Then primary antibody (1% ... View More
产品信息
MA5-49834
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2H12
抗原
A synthesized peptide derived from human Neutrophil Elastase
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_3092474
靶标信息
The neutrophil form of elastase is 218 amino acids long, with two asparagine-linked carbohydrate chains (see glycosylation). It is present in azurophil granules in the neutrophil cytoplasm. There appear to be two forms of neutrophil elastase, termed IIa and IIb.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bone marrow serine protease; ELA2A; Elastase; elastase 2, neutrophil; Elastase-2; Elastase2; granulocyte-derived elastase; HLE; Human leukocyte elastase; leukocyte elastase; Medullasin; Neutrophil elastase; PMN elastase; polymorphonuclear elastase
基因别名: ELA2; ELANE; GE; HLE; HNE; NE; PMN-E; SCN1
UniProt ID: (Human) P08246
Entrez Gene ID: (Human) 1991
negative regulation of transcription from RNA polymerase II promoter
response to yeast
acute inflammatory response to antigenic stimulus
proteolysis
cellular calcium ion homeostasis
phagocytosis
response to UV
extracellular matrix disassembly
protein catabolic process
response to lipopolysaccharide
defense response to bacterium
positive regulation of MAP kinase activity
negative regulation of growth of symbiont in host
negative regulation of chemokine biosynthetic process
negative regulation of interleukin-8 biosynthetic process
positive regulation of interleukin-8 biosynthetic process
positive regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
positive regulation of immune response
leukocyte migration
negative regulation of chemotaxis
neutrophil mediated killing of fungus
