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产品信息
PA5-80033
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human SLC9A1 recombinant protein (Position: H543-Q815).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2747148
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APNH; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1; Na+/H+ antiporter; Na+/H+, amiloride sensitive; Na-Li countertransporter; NHE-1; protein phosphatase 1, regulatory subunit 143; slow-wave epilepsy; Sodium/hydrogen exchanger 1; Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); Solute carrier family 9 member 1; solute carrier family 9, member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
基因别名: APNH; APNH1; AW554487; LIKNS; mir-5122; Mir5122; NHE-1; NHE1; PPP1R143; SLC9A1; swe
UniProt ID: (Human) P19634, (Rat) P26431, (Mouse) Q61165
Entrez Gene ID: (Human) 6548, (Rat) 24782, (Mouse) 20544
protein binding
calmodulin binding
phosphatidylinositol-4,5-bisphosphate binding
solute:proton antiporter activity
sodium:proton antiporter activity
potassium:proton antiporter activity
protein phosphatase 2B binding
protein binding, bridging
protein complex scaffold
calcium-dependent protein binding
sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
antiporter activity
transporter
secondary carrier transporter
ion transport
cellular sodium ion homeostasis
regulation of pH
response to acidic pH
positive regulation of cardiac muscle hypertrophy
regulation of cardiac muscle contraction by calcium ion signaling
cell growth
cell migration
maintenance of cell polarity
hyaluronan catabolic process
positive regulation of cell growth
cellular response to insulin stimulus
positive regulation of mitochondrial membrane permeability
response to muscle stretch
response to drug
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of action potential
positive regulation of transcription from RNA polymerase II promoter
protein oligomerization
regulation of intracellular pH
regulation of stress fiber assembly
positive regulation of NFAT protein import into nucleus
regulation of focal adhesion assembly
regulation of sensory perception of pain
cardiac muscle cell differentiation
positive regulation of calcineurin-NFAT signaling cascade
neuron death
cellular response to antibiotic
cellular response to electrical stimulus
cellular response to mechanical stimulus
sodium ion export
cellular response to hypoxia
cellular response to acidic pH
potassium ion transmembrane transport
cellular response to epinephrine stimulus
cardiac muscle cell contraction
regulation of cardiac muscle cell membrane potential
regulation of the force of heart contraction by cardiac conduction
sodium ion import across plasma membrane
positive regulation of the force of heart contraction
hydrogen ion transmembrane transport
positive regulation of calcium:sodium antiporter activity
regulation of the force of heart contraction
sodium ion transport
response to organic cyclic compound
cell differentiation
sodium ion transmembrane transport
cellular response to organic cyclic compound
positive regulation of intracellular signal transduction
transport
cation transport
embryo development
transmembrane transport
