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产品信息
BS-0181R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from mouse Nociceptin receptor, amino acids 1-47.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: K3 opiate receptor; Kappa-type 3 opioid receptor; kappa3-related opioid receptor; KOR-3; LC132 Receptor-Like; N/OFQ receptor; Nociceptin receptor; nociceptin receptor ORL1; nociceptin/ orphaninFQ receptor; nociceptin/orphanin FQ receptor; opiate receptor-like 1; opioid receptor-like 1; OPPRL1; ORGC; Orphanin FQ receptor; orphanin FQ receptor-a; orphanin FQ receptor-b; orphanin FQ receptor-e; peptide receptor; ROR-C; seven transmembrane G protein-coupled receptor; XOR1
基因别名: KOR-3; KOR3; LC132; MOR-C; morc; NOCIR; NOP; NOPr; OFQR; OOR; Oprl; OPRL1; ORGC; ORL1; XOR1
UniProt ID: (Human) P41146, (Mouse) P35377, (Rat) P35370
Entrez Gene ID: (Human) 4987, (Mouse) 18389, (Rat) 29256
positive regulation of protein phosphorylation
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
chemical synaptic transmission
sensory perception
sensory perception of pain
negative regulation of cAMP biosynthetic process
response to estradiol
positive regulation of urine volume
opioid receptor signaling pathway
eating behavior
estrous cycle
negative regulation of blood pressure
positive regulation of gastric acid secretion
negative regulation of voltage-gated calcium channel activity
positive regulation of sensory perception of pain
regulation of locomotor rhythm
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
behavior
regulation of cAMP biosynthetic process
regulation of sensory perception of pain
