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Nox1/NADPH oxidase 1 Antibody (BS-3682R) in WB
Lane 1: Mouse testis lysates; Lane 2: Mouse uterus lysates; Lane 3: DU145 cell lysates probed with Nox1 Polyclonal Antibody, Unconjugated (bs-3682R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
产品信息
BS-3682R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human Nox1, amino acids 425-515.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv. NOH-1S is a voltage-gated proton channel that participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H (+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 have the potential to be effective treatments for a range of ischemic diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GP91 phox homolog; mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating); Mitogenic oxidase 1; MOX-1; MOX1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NADPH oxidase 1; NADPH oxidase 1 alpha; NADPH oxidase homolog-1; NOH-1; NOX-1
基因别名: GP91-2; MOX1; NOH-1; NOH1; Nox-1; NOX1; NOX1a; NOX1alpha
UniProt ID: (Human) Q9Y5S8, (Rat) Q9WV87, (Mouse) Q8CIZ9
Entrez Gene ID: (Human) 27035, (Rat) 114243, (Mouse) 237038
protein binding
superoxide-generating NADPH oxidase activity
voltage-gated proton channel activity
metal ion binding
Rac GTPase binding
NADP binding
N-ethylmaleimide reductase activity
oxidoreductase activity
reduced coenzyme F420 dehydrogenase activity
sulfur oxygenase reductase activity
malolactic enzyme activity
NADPH:sulfur oxidoreductase activity
epoxyqueuosine reductase activity
oxidase
angiogenesis
regulation of systemic arterial blood pressure by renin-angiotensin
NADP metabolic process
superoxide metabolic process
inflammatory response
signal transduction
regulation of blood pressure
positive regulation of cell proliferation
positive regulation of vascular endothelial growth factor production
proton transport
cell migration
extracellular matrix organization
regulation of ion transmembrane transport
superoxide anion generation
hydrogen peroxide metabolic process
positive regulation of integrin biosynthetic process
respiratory burst
positive regulation of JNK cascade
positive regulation of smooth muscle cell proliferation
intracellular pH elevation
oxidation-reduction process
cellular response to hyperoxia
oxygen metabolic process
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
cellular stress response to acidic pH
response to reactive oxygen species
positive regulation of MAPK cascade
positive regulation of reactive oxygen species metabolic process
transport
cation transmembrane transport
