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OBFC1 Antibody (PA5-81049) in ICC/IF
Immunofluorescence staining of OBFC1 in U251MG cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with OBFC1 Polyclonal Antibody (Product # PA5-81049, 1:1,000) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to nucleus.
产品信息
PA5-81049
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the center region of the Human OBFC1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2788300
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human OBFC1.
靶标信息
OBFC1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha accessory factor 44; CST complex subunit STN1; oligonucleotide/oligosaccharide-binding fold containing 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 1; replication protein A 32 kDa subunit; Suppressor of cdc thirteen homolog
基因别名: AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32; STN1
UniProt ID: (Human) Q9H668
Entrez Gene ID: (Human) 79991
telomere maintenance
telomere maintenance via telomere lengthening
telomere capping
positive regulation of telomere maintenance via telomerase
positive regulation of DNA replication
positive regulation of telomerase activity
negative regulation of telomerase activity
regulation of telomere maintenance via telomere lengthening
