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产品信息
PA5-28842
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region within amino acids 421 and 485 of Human Noelin
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546318
产品详细信息
Recommended positive controls: HepG2, mouse brain.
Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (100%), Chicken (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The Olfactomedin family comprises a diverse group of secreted glycoproteins, which includes OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin and mycocilin. These proteins are implicated in the development of the nervous system. Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8-10, and later in brain tissue and in the zone of polarizing activity in the limb. Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: neuroblastoma protein; Neuronal olfactomedin-related ER localized protein; Noelin; Noelin 1; Noelin 2; olfactomedin related ER localized protein; Olfactomedin-1; Pancortin; pancortin 1; Pancortin 1-4
基因别名: AMY; AW742568; NOE1; Noel; NOEL1; NOELIN1; OlfA; OLFM1; Pancortin; Pancortin3
UniProt ID: (Human) Q99784, (Mouse) O88998
Entrez Gene ID: (Human) 10439, (Mouse) 56177
atrioventricular valve formation
nervous system development
positive regulation of gene expression
negative regulation of gene expression
positive regulation of epithelial to mesenchymal transition
neuronal signal transduction
regulation of axon extension
cardiac epithelial to mesenchymal transition
multicellular organism development
protein oligomerization
regulation of beta-amyloid formation
negative regulation of beta-amyloid formation
negative regulation of neuron migration
