Product References
Modulation of Dendritic Cell Function via Nanoparticle-Induced Cytosolic Calcium Changes.
ACS nano
Cao Z,Yang X,Yang W,Chen F,Jiang W,Zhan S,Jiang F,Li J,Ye C,Lang L,Zhang S,Feng Z,Lai X,Liu Y,Mao L,Cai H,Teng Y,Xie J
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Tue Mar 12 00:00:00 UTC 2024
Metabolic tagging of extracellular vesicles and development of enhanced extracellular vesicle based cancer vaccines.
Nature communications
Bhatta R,Han J,Liu Y,Bo Y,Lee D,Zhou J,Wang Y,Nelson ER,Chen Q,Zhang XS,Hassaneen W,Wang H
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Tue Dec 05 00:00:00 UTC 2023
A modified SELEX approach to identify DNA aptamers with binding specificity to the major histocompatibility complex presenting ovalbumin model antigen.
RSC advances
Lin Y,Chen CY,Ku YC,Wang LC,Hung CC,Lin ZQ,Chen BH,Hung JT,Sun YC,Hung KF
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Tue Oct 31 00:00:00 UTC 2023
CD73 Inhibits cGAS-STING and Cooperates with CD39 to Promote Pancreatic Cancer.
Cancer immunology research
Jacoberger-Foissac C,Cousineau I,Bareche Y,Allard D,Chrobak P,Allard B,Pommey S,Messaoudi N,McNicoll Y,Soucy G,Koseoglu S,Masia R,Lake AC,Seo H,Eeles CB,Rohatgi N,Robson SC,Turcotte S,Haibe-Kains B,Stagg J
17-5743-82 was used in Flow cytometry/Cell sorting to investigate biological impacts of CD39 and CD73 in pancreatic ductal adenocarcinoma (PDAC) by studying clinical samples and experimental mouse tumors.
Tue Jan 03 00:00:00 UTC 2023
Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.
The Journal of clinical investigation
Ren J,Li N,Pei S,Lian Y,Li L,Peng Y,Liu Q,Guo J,Wang X,Han Y,Zhang G,Wang H,Li Y,Jiang J,Li Q,Tan M,Peng J,Hu G,Xiao Y,Li X,Lin M,Qin J
17-5743-82 was used in Flow Cytometry to establish a tumor-suppressive function of WHSC1 that relays IFN-γ signaling to promote antigen presentation in CRC cells, and provide a rationale for boosting WHSC1 activity in immunotherapy.
Fri Apr 15 00:00:00 UTC 2022
RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer.
The Journal of clinical investigation
Deng P,Wang Z,Chen J,Liu S,Yao X,Liu S,Liu L,Yu Z,Huang Y,Xiong Z,Xiao R,Gao J,Liang W,Chen J,Liu H,Hong JH,Chan JY,Guan P,Chen J,Wang Y,Yin J,Li J,Zheng M,Zhang C,Zhou P,Kang T,Teh BT,Yu Q,Zuo Z,Jiang Q,Liu J,Xiong Y,Xia X,Tan J
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Tue Nov 15 00:00:00 UTC 2022
Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.
Journal for immunotherapy of cancer
Wang Z,Xu F,Hu J,Zhang H,Cui L,Lu W,He W,Wang X,Li M,Zhang H,Xiong W,Xie C,Liu Y,Zhou P,Liu J,Huang P,Qin XF,Xia X
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Sat May 01 00:00:00 UTC 2021
Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.
Journal for immunotherapy of cancer
Wang Z,Xu F,Hu J,Zhang H,Cui L,Lu W,He W,Wang X,Li M,Zhang H,Xiong W,Xie C,Liu Y,Zhou P,Liu J,Huang P,Qin XF,Xia X
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Sat May 01 00:00:00 UTC 2021
Titrating Polyarginine into Nanofibers Enhances Cyclic-Dinucleotide Adjuvanticity in Vitro and after Sublingual Immunization.
ACS biomaterials science & engineering
Kelly SH,Cossette BJ,Varadhan AK,Wu Y,Collier JH
17-5743-82 was used in Flow cytometry/Cell sorting to present a potentially generalizable biomaterial strategy for enhancing the potency of CDN adjuvants and reveal important design considerations for the nascent field of sublingual biomaterial immunization.
Mon May 10 00:00:00 UTC 2021
β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway.
Cell
Ghosh S,Dellibovi-Ragheb TA,Kerviel A,Pak E,Qiu Q,Fisher M,Takvorian PM,Bleck C,Hsu VW,Fehr AR,Perlman S,Achar SR,Straus MR,Whittaker GR,de Haan CAM,Kehrl J,Altan-Bonnet G,Altan-Bonnet N
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Thu Dec 10 00:00:00 UTC 2020
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity.
Nature communications
von Roemeling CA,Wang Y,Qie Y,Yuan H,Zhao H,Liu X,Yang Z,Yang M,Deng W,Bruno KA,Chan CK,Lee AS,Rosenfeld SS,Yun K,Johnson AJ,Mitchell DA,Jiang W,Kim BYS
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Fri Mar 20 00:00:00 UTC 2020
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity.
Nature communications
von Roemeling CA,Wang Y,Qie Y,Yuan H,Zhao H,Liu X,Yang Z,Yang M,Deng W,Bruno KA,Chan CK,Lee AS,Rosenfeld SS,Yun K,Johnson AJ,Mitchell DA,Jiang W,Kim BYS
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Fri Mar 20 00:00:00 UTC 2020
Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells.
Cell
Miao Y,Yang H,Levorse J,Yuan S,Polak L,Sribour M,Singh B,Rosenblum MD,Fuchs E
17-5743 was used in Flow cytometry/Cell sorting to place tSCs at the crux of how immune checkpoint pathways are activated.
Thu May 16 00:00:00 UTC 2019
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Tue Aug 13 00:00:00 UTC 2019
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Tue Aug 13 00:00:00 UTC 2019
Autophagy protein ATG5 regulates CD36 expression and anti-tumor MHC class II antigen presentation in dendritic cells.
Autophagy
Oh DS,Lee HK
17-5743-82 was used in Flow cytometry/Cell sorting to demonstrate that Atg5 is required for proper antigen phagocytosis and presentation to MHC class II via modulation of CD36 in dendritic cells and may be a future therapeutic target for anti-tumor therapy.
Sun Dec 01 00:00:00 UTC 2019
Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions.
Nature communications
Lin JC,Chien CY,Lin CL,Yao BY,Chen YI,Liu YH,Fang ZS,Chen JY,Chen WY,Lee NN,Chen HW,Hu CJ
17-5743 was used in Flow cytometry/Cell sorting to create a versatile cell fixation approach adaptable for biomembrane studies and biomedical device construction.
Tue Mar 05 00:00:00 UTC 2019
SMAC Mimetic Debio 1143 and Ablative Radiation Therapy Synergize to Enhance Antitumor Immunity against Lung Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Tao Z,McCall NS,Wiedemann N,Vuagniaux G,Yuan Z,Lu B
17-5743-82 was used in Flow Cytometry to show that Debio 1143 augments the tumor-specific adaptive immunity induced by ART, while reversing host immunosuppressive cell infiltrates in the tumor microenvironment in a TNFα, IFNγ, and CD8+ T-cell-dependent manner.
Fri Feb 01 00:00:00 UTC 2019
Reprogramming MHC specificity by CRISPR-Cas9-assisted cassette exchange.
Scientific reports
Kelton W,Waindok AC,Pesch T,Pogson M,Ford K,Parola C,Reddy ST
17-5743 was used in Flow cytometry/Cell sorting to demonstrate a proof-of-concept for reprogramming MHC-specificity by performing CRISPR-Cas9-assisted cassette exchange.
Tue Apr 04 00:00:00 UTC 2017
Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes.
Viruses
Setz C,Friedrich M,Rauch P,Fraedrich K,Matthaei A,Traxdorf M,Schubert U
17-5743 was used in Flow cytometry/Cell sorting to show that the DUB-inhibitors P22077 and PR-619 impair Gag processing and thereby reduce the infectivity of released virions without affecting viral protease activity.
Sat Aug 12 00:00:00 UTC 2017
Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner.
PloS one
Hahn F,Schmalen A,Setz C,Friedrich M,Schlößer S,Kölle J,Spranger R,Rauch P,Fraedrich K,Reif T,Karius-Fischer J,Balasubramanyam A,Henklein P,Fossen T,Schubert U
17-5743 was used in Flow cytometry/Cell sorting to investigate the function of HIV-1 p6 following its proteolytic release from Gag.
Thu Sep 07 00:00:00 UTC 2017
S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Nature immunology
Wang F,Alain T,Szretter KJ,Stephenson K,Pol JG,Atherton MJ,Hoang HD,Fonseca BD,Zakaria C,Chen L,Rangwala Z,Hesch A,Chan ESY,Tuinman C,Suthar MS,Jiang Z,Ashkar AA,Thomas G,Kozma SC,Gale M,Fitzgerald KA,Diamond MS,Mossman K,Sonenberg N,Wan Y,Lichty BD
17-5743 was used in Flow cytometry/Cell sorting to regulate cytosolic DNA-mediated activation of the transcription factor IRF3 using S6K-STING interaction.
Sun May 01 00:00:00 UTC 2016
Glutamic Acid Residues in HIV-1 p6 Regulate Virus Budding and Membrane Association of Gag.
Viruses
Friedrich M,Setz C,Hahn F,Matthaei A,Fraedrich K,Rauch P,Henklein P,Traxdorf M,Fossen T,Schubert U
17-5743 was used in Flow cytometry/Cell sorting to indicate that the glutamic acids within p6 contribute to the late steps of viral replication.
Mon Apr 25 00:00:00 UTC 2016
Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines.
PloS one
Martin SD,Brown SD,Wick DA,Nielsen JS,Kroeger DR,Twumasi-Boateng K,Holt RA,Nelson BH
17-5743 was used in Flow cytometry/Cell sorting to highlight the limitations of applying neoantigen-targeted vaccines to tumor types with intermediate/low mutation burdens.
Fri Jul 07 00:00:00 UTC 2017
KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation.
The EMBO journal
Brooks CR,Yeung MY,Brooks YS,Chen H,Ichimura T,Henderson JM,Bonventre JV
17-5743 was used in Flow cytometry/Cell sorting to investigate the role of KIM-1/TIM-1 in phagocytosis, showing that they link ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation.
Thu Oct 01 00:00:00 UTC 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Thu Apr 28 00:00:00 UTC 2016
Oxidized lipids block antigen cross-presentation by dendritic cells in cancer.
Journal of immunology (Baltimore, Md. : 1950)
Ramakrishnan R,Tyurin VA,Veglia F,Condamine T,Amoscato A,Mohammadyani D,Johnson JJ,Zhang LM,Klein-Seetharaman J,Celis E,Kagan VE,Gabrilovich DI
Published figure using OVA257-264 (SIINFEKL) peptide bound to H-2Kb monoclonal antibody (Product # 17-5743-82) in Flow Cytometry
Sat Mar 15 00:00:00 UTC 2014
Mutation of the highly conserved Ser-40 of the HIV-1 p6 gag protein to Phe causes the formation of a hydrophobic patch, enhances membrane association, and polyubiquitination of Gag.
Viruses
Hahn F,Setz C,Friedrich M,Rauch P,Solbak SM,Frøystein NA,Henklein P,Votteler J,Fossen T,Schubert U
17-5743 was used in Flow cytometry/Cell sorting to study the effects of the S40F mutation in the HIV p6 gag protein.
Thu Oct 02 00:00:00 UTC 2014
Minicircle DNA is superior to plasmid DNA in eliciting antigen-specific CD8+ T-cell responses.
Molecular therapy : the journal of the American Society of Gene Therapy
Dietz WM,Skinner NE,Hamilton SE,Jund MD,Heitfeld SM,Litterman AJ,Hwu P,Chen ZY,Salazar AM,Ohlfest JR,Blazar BR,Pennell CA,Osborn MJ
17-5743 was used in Flow cytometry/Cell sorting to determine that intradermal delivery of minicircle DNA may prove more efficacious for prophylaxis than traditional pDNA vaccines.
Thu Aug 01 00:00:00 UTC 2013
Kinetics of antigen expression and epitope presentation during virus infection.
PLoS pathogens
Croft NP,Smith SA,Wong YC,Tan CT,Dudek NL,Flesch IE,Lin LC,Tscharke DC,Purcell AW
17-5743 was used in Flow cytometry/Cell sorting to quantify the presentation of eight vaccinia virus peptide-MHC complexes (epitopes) on infected cells and the amounts of their source antigens at multiple times after infection.
Tue Jan 01 00:00:00 UTC 2013
Just one position-independent lysine residue can direct MelanA into proteasomal degradation following N-terminal fusion of ubiquitin.
PloS one
Setz C,Friedrich M,Hahn S,Dörrie J,Schaft N,Schuler G,Schubert U
17-5743 was used in Flow cytometry/Cell sorting to analyse the requirement of the ubiquitin fusion degradation pathway for ubiquitination and proteasomal degradation of a transmembrane protein.
Mon Aug 26 00:00:00 UTC 2013
The PTAP sequence within the p6 domain of human immunodeficiency virus type 1 Gag regulates its ubiquitination and MHC class I antigen presentation.
Journal of immunology (Baltimore, Md. : 1950)
Hahn S,Setz C,Wild J,Schubert U
17-5743 was used in Flow cytometry/Cell sorting to identify a naturally occurring sequence motif within Gag that regulates its entry into the defective ribosomal products pathway.
Sun May 15 00:00:00 UTC 2011
The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation.
Virology
Kwun HJ,da Silva SR,Qin H,Ferris RL,Tan R,Chang Y,Moore PS
17-5743 was used in Flow cytometry/Cell sorting to investigate the localisation of MHC I inhibiting function on the latency associated-nuclear antigen 1 from Kaposi's sarcoma-associated herpesvirus.
Sun Apr 10 00:00:00 UTC 2011
Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition.
Cell host & microbe
Alzhanova D,Edwards DM,Hammarlund E,Scholz IG,Horst D,Wagner MJ,Upton C,Wiertz EJ,Slifka MK,Früh K
17-5743 was used in Flow cytometry/Cell sorting to identify cowpox virus proteins that mediate T cell evasion in multiple hosts.
Thu Nov 19 00:00:00 UTC 2009
Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition.
Cell host & microbe
Alzhanova D,Edwards DM,Hammarlund E,Scholz IG,Horst D,Wagner MJ,Upton C,Wiertz EJ,Slifka MK,Früh K
17-5743 was used in Flow cytometry/Cell sorting to identify cowpox virus proteins that mediate T cell evasion in multiple hosts.
Thu Nov 19 00:00:00 UTC 2009