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OX40 Antibody (MA5-23591) in Flow
Flow cytometry of OX40 in Human peripheral blood mononuclear cells (PBMCs) stained with Mouse Anti-Human CD3 PE‚conjugated Monoclonal Antibody. Samples were incubated in either (A) OX40 monoclonal antibody (Product # MA5-23591) or (B) Rat IgG2A Allophycocyanin Isotype Control.
产品信息
MA5-23591
产品规格
种属反应
Human
宿主/亚型
Rat
/ IgG2A
分类
Monoclonal
类型
Antibody
克隆号
443318
抗原
Mouse myeloma cell line NS0-derived recombinant human OX40/TNFRSF4 Leu29-Ala216
偶联物
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
纯化类型
Protein A/G
保存液
Buffered saline solution with BSA
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2608752
产品详细信息
In Western blots, no cross-reactivity with recombinant human (rh) 4-1BB, rhBAFF R, rhCD27, rhCD30, rhCD40, rhDR3, rhDR6, rhEDAR, rhFAS, rhGITR, rhHVEM, rhLT beta R, rhNGF R, rhRANK, rhRELT, rhTAJ, rhTNF RI, rhTNF RII, rhTRAIL, rhTRAIL R4, rhTRAIL R3, rhTWEAK R, or rhXEDAR is observed.
靶标信息
OX40 is a protein receptor found on the surface of T cells, a type of white blood cell that plays a crucial role in the immune system. When activated, OX40 promotes the proliferation and survival of T cells, leading to a stronger immune response against cancer cells and infectious agents. OX40 agonists, which are drugs that activate OX40, have shown promising results in preclinical and clinical studies as a potential immunotherapy for cancer. They can enhance the efficacy of other cancer treatments such as chemotherapy and checkpoint inhibitors, and may also have applications in autoimmune diseases and allergies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACT35 antigen; ATC35 antigen; CD134; CD134 antigen; lymphoid activation antigene ACT35; OX40 antigen; OX40 cell surface antigen; OX40 homologue; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor; Tumor necrosis factor receptor superfamily member 4; tumor necrosis factor receptor superfamily, member 4
基因别名: ACT35; CD134; IMD16; OX40; TNFRSF4; TXGP1L
UniProt ID: (Human) P43489
Entrez Gene ID: (Human) 7293
inflammatory response
immune response
multicellular organism development
positive regulation of B cell proliferation
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
T cell proliferation
regulation of cell proliferation
regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
viral entry into host cell
positive regulation of immunoglobulin secretion
apoptotic signaling pathway
