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Osteopontin (SPP1) Antibody (600-600) in IHC (P)
Immunohistochemistry:Human breast cancer tissue (FFPE) stained with Rabbit anti Osteopontin/SPP1 antibody (Cat# 600-600) at 1:100 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
产品信息
600-600
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the internal portion of Osteopontin protein sequence
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with proprietary stabilizer
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive control: HT-29 cells
Cellular location: Cytoplasmic.
靶标信息
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2AR; 44 kDa bone phosphoprotein; Bone sialoprotein 1; Bone sialoprotein 1 (BSPI/BSP1); Calcium oxalate crystal growth inhibitor protein; CALPHA1 fusion; Early T lymphocyte activation 1 (ETA1); early T-lymphocyte activation 1; Early T-lymphocyte activation 1 protein; HGNC:11255; immunoglobulin alpha 1 heavy chain constant region fusion protein; MGC110940; Minopontin; Nephropontin; Osteopontin; osteopontin-like protein; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; Secreted phosphoprotein 1; secreted phosphoprotein 1 (osteopontin bone sialoprotein I early T lymphocyte activation 1); secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); Secreted phosphoprotein 1 (SPP1); secreted phosphoprotein 1 variant 6; Sialoprotein (osteopontin); SPP-1; SPP1/CALPHA1 fusion; urinar; Urinary stone protein; Uropontin
基因别名: 2AR; 2b7; Apl-1; BNSP; Bsp; BSPI; Eta; ETA-1; OP; OPN; Opnl; OSP; PSEC0156; Ric; Spp-1; SPP1
UniProt ID: (Human) P10451, (Mouse) P10923, (Rat) P08721
Entrez Gene ID: (Human) 6696, (Mouse) 20750, (Rat) 25353
osteoblast differentiation
inflammatory response
cell adhesion
embryo implantation
extracellular matrix disassembly
extracellular matrix organization
biomineral tissue development
response to vitamin D
positive regulation of bone resorption
decidualization
response to steroid hormone
negative regulation of collateral sprouting of intact axon in response to injury
ossification
response to organic substance
positive regulation of cell-substrate adhesion
neutrophil chemotaxis
negative regulation of apoptotic process
cellular response to fluid shear stress
cell differentiation
