Invitrogen

P-Selectin Monoclonal Antibody (Psel.KO.2.7)

P-Selectin Antibody in Flow Cytometry (Flow)

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P-Selectin Antibody (MA1-81809) in Flow

Flow cytometric analysis of thrombin activated canine platelets using a CD62P/P-selectin monoclonal antibody (Product # MA1-81809)

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产品信息

MA1-81809

应用

建议稀释比

已发表文章

免疫组化（冰冻） (IHC (F))

Assay-dependent

流式细胞分析 (Flow)

1:25-1:50

免疫沉淀 (IP)

Assay-dependent

产品规格

种属反应

Bovine, Horse, Cat, Goat, Human, Mouse, Sheep, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

Psel.KO.2.7

抗原

P-selectin transfected 300.19 cells.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2184952

产品详细信息

For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.

Mouse anti human CD62P, clone Psel.KO.2.7, recognizes human P-Selectin.

靶标信息

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CD62; CD62 antigen-like family member P; CD62P; CD62P antigen; FLJ45155; GMP-140; Granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; LECAM3; Leukocyte-endothelial cell adhesion molecule 3; P-selectin; PADGEM; Platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; RP1-86F14.2; selectin P (granule membrane protein 140kDa, antigen CD62); selectin, platelet

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基因别名: CD62; CD62P; GMP-140; GMP140; GMRP; GRMP; LECAM3; PADGEM; PSEL; PSELECT; SELP