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P2X1 Receptor (extracellular) Antibody (APR-022-200UL) in ICC/IF
Expression of P2X1 Receptor in human SH-SYS5 cells - Cell surface detection of P2X1 Receptor inintact livinghuman SH-SYS5 cells. A. Extracellular staining of cells with Anti-P2X1 Receptor (extracellular) Antibody (#APR-022), (1:50) followed by goat Anti-rabbit-AlexaFluor-488 secondary Antibody .B. Nuclear staining DAPI as the counterstain.C. Merged images of A and B.
产品信息
APR-022-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CRPIYEFHGLYEEK, corresponding to amino acid residues 270-283 of human P2X1 receptor, Extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP receptor; P2X purinoceptor 1; P2X receptor, subunit 1; P2X1; P2X1 receptor; programmed cell death 3; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 1; purinergic receptor P2X, ligand-gated ion channel, 1; purinergic receptor P2X1; RP-2 protein
基因别名: AI323649; BB122383; P2RX1; P2x; P2X1; P2XMR; Pdcd3; RP-2
UniProt ID: (Human) P51575, (Rat) P47824, (Mouse) P51576
Entrez Gene ID: (Human) 5023, (Rat) 25505, (Mouse) 18436
serotonin secretion by platelet
regulation of vascular smooth muscle contraction
transport
ion transport
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
insemination
blood coagulation
regulation of blood pressure
neuronal action potential
platelet activation
response to ATP
synaptic transmission, glutamatergic
purinergic nucleotide receptor signaling pathway
vasoconstriction
positive regulation of ion transport
ceramide biosynthetic process
protein homooligomerization
protein heterooligomerization
regulation of calcium ion transport
cation transmembrane transport
cation transport
regulation of smooth muscle contraction
response to organic substance
regulation of vasoconstriction
