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产品信息
P2Y1-101AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Cat,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 360-410 on rat P2Y1.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
P2Y1 is a Purinergic Receptor that causes a change in platelet shape and potentially leads to platelet aggregation by binding ADP, which results in the mobilization of intracellular calcium ions via activation of phospholipase C. This receptor also mediates the release of the relaxing factor nitric oxide and may be involved in the modulation of neuronal signal transmission. P2Y1 has been reported to be expressed in tissues throughout the body, particularly brain. ESTs have been isolated from human embryo, lung, and placenta libraries.
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生物信息学
蛋白别名: ADP receptor; ATP receptor; P2 purinoceptor subtype Y1; P2 purinoreceptor subclass 2Y; P2Y ATP receptor 1; P2Y purinoceptor 1; p2y-1-r; P2Y1; P2Y1 receptor; p2y1r; platelet ADP receptor; Purinergic receptor; purinergic receptor P2Y, G-protein coupled, 1; Purinoceptor p2y1; Purinoceptor p2yr1
基因别名: P2RY1; P2y; P2Y1
UniProt ID: (Human) P47900, (Rat) P49651, (Mouse) P49650
Entrez Gene ID: (Human) 5028, (Rat) 25265, (Mouse) 18441
receptor activity
protein binding
ATP binding
A1 adenosine receptor binding
ADP binding
G-protein coupled purinergic nucleotide receptor activity
ATP-activated adenosine receptor activity
ADP-activated adenosine receptor activity
protein heterodimerization activity
scaffold protein binding
signal transducer activity
G-protein coupled receptor activity
G-protein coupled receptor
positive regulation of protein phosphorylation
adenosine receptor signaling pathway
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
aging
glial cell migration
response to mechanical stimulus
regulation of receptor activity
negative regulation of norepinephrine secretion
sensory perception of pain
signal transduction involved in regulation of gene expression
platelet activation
positive regulation of inositol trisphosphate biosynthetic process
G-protein coupled purinergic nucleotide receptor signaling pathway
regulation of vasodilation
eating behavior
positive regulation of ion transport
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hormone secretion
negative regulation of binding
positive regulation of penile erection
positive regulation of ERK1 and ERK2 cascade
response to growth factor
cellular response to organic cyclic compound
protein localization to plasma membrane
relaxation of muscle
wound healing
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
signal transduction
