Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 3
P2Y12 Receptor (extracellular) Antibody (APR-020-GP200UL) in ICC/IF
Expression of P2RY12 in human glioblastoma (U-87 MG) cells - Cell surface detection of P2RY12 in intact living U-87 MG cells. A. Extracellular staining of cells using Guinea pig Anti-P2Y12 Receptor (extracellular) Antibody (#APR-020-GP), (1:100) followed by goat Anti-guinea pig-AlexaFluor-594 secondary Antibody (red). DAPI was used as the counterstain (blue). B. Live view of the cells merged with P2Y12 stai... View More
产品信息
APR-020-GP200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Guinea pig
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CTAENTLFYVKES, corresponding to amino acid residues 270-282 of human P2RY12, 3rd extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
P2Y12 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene. Expression of P2Y12 has been reported in platelets, spinal cord, and many brain regions. ESTs for P2Y12 have been isolated from B-cell/lung/testis, brain, embryo, prostate, eye, kidney carcinoma, and colon carcinoma libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: ADP-glucose receptor; ADPG-R; G-protein coupled receptor SP1999; Gi-coupled ADP receptor HORK3; P2T(AC); P2Y purinoceptor 12; P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; P2Y12 platelet ADP receptor; P2YR12; purinergic receptor P2RY12; purinergic receptor P2Y, G-protein coupled, 12; putative G-protein coupled receptor; SP1999
基因别名: 2900079B22Rik; 4921504D23Rik; ADPG-R; BDPLT8; HORK3; P2RY12; P2T(AC); P2Y(12)R; P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; SP1999
UniProt ID: (Human) Q9H244, (Mouse) Q9CPV9, (Rat) Q9EPX4
Entrez Gene ID: (Human) 64805, (Mouse) 70839, (Rat) 64803
adenosine receptor signaling pathway
substrate-dependent cell migration, cell extension
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
hemostasis
glial cell migration
negative regulation of norepinephrine secretion
G-protein coupled purinergic nucleotide receptor signaling pathway
positive regulation of ion transport
protein kinase B signaling
positive regulation of GTPase activity
negative regulation of cell differentiation
regulation of calcium ion transport
platelet aggregation
calcium ion transmembrane transport
cellular response to ATP
potassium ion transmembrane transport
regulation of microglial cell migration
signal transduction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
blood coagulation
cell projection organization
platelet activation
cellular response to organic cyclic compound
