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This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cell cycle protein p38-2G4 homolog; ErbB-3 binding protein 1; ErbB3-binding protein 1; ErbB3-binding protein Ebp1; hG4 1; hG4-1; IRES-specific cellular trans-acting factor 45 kDa; ITAF45; MGC81621; MGC94070; Mpp1; p38 2G4; proliferation-associated 2G4, 38kD; proliferation-associated 2G4, 38kDa; Proliferation-associated protein 1; Proliferation-associated protein 2G4; Protein p38-2G4; si:dz150i12.2; wu:fb19b11; wu:ft56d05; zgc:86732
基因别名: 38kDa; AA672939; EBP1; HG4-1; p38-2G4; PA2G4; Plfap
UniProt ID: (Human) Q9UQ80, (Rat) Q6AYD3, (Mouse) P50580
Entrez Gene ID: (Human) 5036, (Rat) 288778, (Mouse) 18813