Search Thermo Fisher Scientific
Immunogen sequence: GNIYQLDVRS PRAPVQVIHR SGAPVLSLLS VRDGFIASQG DGSCFIVQQD LDYVTELTGA DCDPVYKVAT WEKQIYTCCR DGLVRRYQLS DL
Highest antigen sequence identity to the following orthologs: Mouse - 20%, Rat - 22%.
PAAF1 inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Proteasomal ATPase-associated factor 1; Protein G-16; WD repeat domain 71; WD repeat-containing protein 71
基因别名: PAAF; PAAF1; Rpn14; WDR71
UniProt ID: (Human) Q9BRP4
Entrez Gene ID: (Human) 80227