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产品信息
CL488-66386
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
2D8C12
抗原
Recombinant Protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, store in dark
运输条件
Wet ice
靶标信息
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
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生物信息学
蛋白别名: PAD type II; PAD-H19; peptidyl arginine deiminase, type 2; peptidyl arginine deiminase, type II; peptidyl arginine deiminase, type II; PAD type II; Peptidylarginine deiminase II; Protein-arginine deiminase type II; Protein-arginine deiminase type-2; RP1-37C10.6
基因别名: KIAA0994; mKIAA0994; PAD-H19; PAD2; PADI2; Pdi; PDI2
UniProt ID: (Human) Q9Y2J8, (Rat) P20717, (Mouse) Q08642
Entrez Gene ID: (Human) 11240, (Rat) 29511, (Mouse) 18600
regulation of chromatin disassembly
protein citrullination
substantia nigra development
intracellular estrogen receptor signaling pathway
histone H3-R26 citrullination
chromatin-mediated maintenance of transcription
negative regulation of chemokine-mediated signaling pathway
negative regulation of lymphocyte chemotaxis
chromatin organization
