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PAK1 Antibody (PA5-118139) in ICC/IF
Immunocytochemistry analysis of PAK1 in HeLa cells. Samples were treated with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, incubated with polyclonal antibody (Product # PA5-118139) with a dilution of 1:5,000 (4°C overnight), followed by Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and DAPI (blue).
产品信息
PA5-118139
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the C-terminus of the Rat PAK1
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2902739
靶标信息
PAK1 is a serine/threonine kinase that is a target for restenosis, cancer, and immunosuppression treatment. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADRB2; alpha pak; Alpha-PAK; EC 2.7.11.1; kinase PAK1; MGC130000; MGC130001; p21 (CDKN1A)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p68-PAK; PAK 1; PAK-1; PAK1B; Protein kinase MUK2; Serine/threonine-protein kinase PAK 1
基因别名: Pak1
UniProt ID: (Rat) P35465
Entrez Gene ID: (Rat) 29431
MAPK cascade
activation of MAPKK activity
mitotic cell cycle
response to hypoxia
positive regulation of protein phosphorylation
protein phosphorylation
exocytosis
apoptotic process
small GTPase mediated signal transduction
axonogenesis
neuromuscular junction development
response to organic substance
dendrite development
actin cytoskeleton reorganization
cellular response to insulin stimulus
regulation of actin cytoskeleton organization
positive regulation of peptidyl-serine phosphorylation
positive regulation of intracellular estrogen receptor signaling pathway
intracellular signal transduction
wound healing
receptor clustering
positive regulation of JUN kinase activity
protein autophosphorylation
branching morphogenesis of an epithelial tube
neuron projection morphogenesis
positive regulation of stress fiber assembly
negative regulation of cell proliferation involved in contact inhibition
