Search Thermo Fisher Scientific
Recommended positive controls: PC-3, U87-MG.
Predicted reactivity: Mouse (91%), Rat (91%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP16 is a member of poly(ADP-ribose) polymerases (PARPs) family that is encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ADP-ribosyltransferase diphtheria toxin-like 15; PARP-16; poly (ADP-ribose) polymerase family, member 16; Poly [ADP-ribose] polymerase 16; Protein mono-ADP-ribosyltransferase PARP16
基因别名: ARTD15; C15orf30; PARP16; pART15
UniProt ID: (Human) Q8N5Y8
Entrez Gene ID: (Human) 54956