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产品信息
PA5-55475
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2645218
产品详细信息
Immunogen sequence: QLHGAAYGKG IYLSPISSIS FGYSGMGKGQ HRMPSKDELV QRYNRMNTIP QTRSIQSRFL QSRNLNCIAL CEVITSKDLQ KHG
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
靶标信息
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADP-ribosyltransferase diphtheria toxin-like 17; ARTD17; PARP-6; poly (ADP-ribose) polymerase family, member 6; Poly [ADP-ribose] polymerase 6; Protein mono-ADP-ribosyltransferase PARP6
基因别名: ARTD17; PARP-6-B1; PARP-6-C; PARP6; pART17
UniProt ID: (Human) Q2NL67
Entrez Gene ID: (Human) 56965
