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PAX5 Antibody (MA5-16389) in IHC (P)
Immunohistochemistry was performed on formalin-fixed paraffin-embedded canine lymph node tissue sections. Antigen retrieval was performed by heating tissues in 10mM sodium citrate buffer, pH 9.0 for 20 minutes. Tissues were blocked in 10% normal goat serum containing 2X casein for 30 minutes at room temperature and probed with a PAX5 monoclonal antibody, clone SP34 (Product # MA1-39420) for 1.5 hours at 37°... View More
产品信息
MA5-16389
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
SP34
抗原
Synthetic peptide from C-terminus of human Pax-5 protein
偶联物
形式
Liquid
浓度
0.067 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.6, with 1% BSA
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2537908
产品详细信息
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is tonsil tissue.
靶标信息
PAX5 is a member of the paired box (PAX) family of transcription factors. The PAX proteins are important regulators in early development and alterations in the expression of their genes are thought to contribute to neoplastic transformation. PAX5 is the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages, of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. Mutations in the gene can result in leukemia, acute lymphoblastic 3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: B-cell lineage specific activator; B-cell-specific transcription factor; BSAP; paired box homeotic gene 5; Paired box protein Pax-5; paired domain gene 5; transcription factor PAX 5
基因别名: ALL3; BSAP; PAX5; RGD1565236
UniProt ID: (Human) Q02548
Entrez Gene ID: (Human) 5079, (Rat) 500453
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
skeletal muscle cell differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of histone H3-K9 methylation
humoral immune response
multicellular organism development
spermatogenesis
aging
organ morphogenesis
lateral ventricle development
cerebral cortex development
adult behavior
embryonic cranial skeleton morphogenesis
