Invitrogen

PAX6 Recombinant Rabbit Monoclonal Antibody (SD081-03)

查看其他39个PAX6抗体

抗体检测数据 (4)

PAX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PAX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PAX6 Antibody (MA5-32379) in IHC (P)

Immunohistochemical analysis of PAX6 of paraffin-embedded Mouse eyes tissue using a PAX6 Monoclonal antibody (Product #MA5-32379). Counter stained with hematoxylin.

PAX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PAX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PAX6 Antibody in Western Blot (WB)

PAX6 Antibody in Flow Cytometry (Flow)

Product Image Gallery

PAX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of PAX6 of paraffin-embedded Mouse eyes tissue using a PAX6 Monoclonal antibody (Product #MA5-32379). Counter stained with hematoxylin.

PAX6 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of PAX6 of paraffin-embedded rat eyes tissue using a PAX6 Monoclonal antibody (Product #MA5-32379). Counter stained with hematoxylin.

PAX6 Antibody in Western Blot (WB) — Western blot analysis of PAX6 in mouse eye lysate using a PAX6 Monoclonal antibody (Product # MA5-32379) at a dilution of 1:1,000.

PAX6 Antibody in Flow Cytometry (Flow) — Flow Cytometric analysis of PAX6 in SH-SY-5Y cells using a PAX6 Monoclonal Antibody (Product # MA5-32379) at a dilution of 1:50, as seen in red compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the ssecondary antibody.

产品信息

MA5-32379

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:5000

-

免疫组化（石蜡） (IHC (P))

1:200-1:2000

-

流式细胞分析 (Flow)

1:50-1:100

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

SD081-03

抗原

Synthetic peptide within Human PAX6 aa 373-422

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2809659

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Aniridia; Aniridia type II protein; Dickie's small eye; Keratitis; MGC17209; Oculorhombin; paired box gene 6; Paired Box Gene-6; paired box homeotic gene 6; paired box homeotic gene-6; Paired box protein Pax-6; small eye

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基因别名: 1500038E17Rik; AEY11; AN; AN2; D11S812E; Dey; FVH1; Gsfaey11; MGDA; Pax-6; PAX6; Sey; WAGR

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UniProt ID: (Human) P26367, (Rat) P63016, (Mouse) P63015

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Entrez Gene ID: (Human) 5080, (Rat) 25509, (Mouse) 18508

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RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding ubiquitin-protein transferase activity protein binding transcription factor binding protein kinase binding ubiquitin protein ligase binding histone acetyltransferase binding co-SMAD binding R-SMAD binding HMG box domain binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding AT DNA binding double-stranded DNA binding sequence-specific DNA binding transcription regulatory region DNA binding

参与通路

negative regulation of transcription from RNA polymerase II promoter establishment of mitotic spindle orientation blood vessel development cell fate determination neural crest cell migration neuron migration negative regulation of protein phosphorylation positive regulation of neuroblast proliferation epithelial cell development lens development in camera-type eye type B pancreatic cell differentiation pancreatic A cell differentiation pancreatic A cell development regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter smoothened signaling pathway axonogenesis axon guidance central nervous system development brain development salivary gland morphogenesis negative regulation of cell proliferation response to wounding regulation of asymmetric cell division dorsal/ventral axis specification anterior/posterior pattern specification dorsal/ventral pattern formation regulation of gene expression positive regulation of gene expression regulation of neuron projection development protein ubiquitination spinal cord development pallium development cerebellum development rhombomere morphogenesis olfactory bulb development oligodendrocyte cell fate specification cerebral cortex regionalization forebrain anterior/posterior pattern specification forebrain dorsal/ventral pattern formation commitment of neuronal cell to specific neuron type in forebrain forebrain-midbrain boundary formation regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment telencephalon regionalization pituitary gland development interkinetic nuclear migration signal transduction involved in regulation of gene expression cell differentiation keratinocyte differentiation regulation of cell migration positive regulation of epithelial cell differentiation forebrain development hindbrain development lacrimal gland development cellular response to insulin stimulus protein localization to organelle cellular response to drug eye photoreceptor cell development glucose homeostasis positive regulation of cell fate specification camera-type eye development cellular response to fibroblast growth factor stimulus cell fate commitment response to ethanol regulation of neuron differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of timing of cell differentiation embryonic camera-type eye morphogenesis astrocyte differentiation negative regulation of epithelial cell proliferation regulation of neurogenesis negative regulation of neurogenesis retina development in camera-type eye iris morphogenesis cornea development in camera-type eye neural precursor cell proliferation positive regulation of glucagon secretion cellular response to glucose stimulus cellular response to prostaglandin E stimulus insulin metabolic process negative regulation of neural precursor cell proliferation positive regulation of neuron migration eye development visual perception organ morphogenesis neuron fate commitment transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development