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PAX8 Monoclonal Antibody (3H7)

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产品信息

H00007849-M09C

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

-

酶联免疫吸附实验 (ELISA)

10 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

3H7

抗原

PAX8 (AAH01060.1, 1 a.a. approximately 450 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

保存液

tissue culture supernatant

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP TMFAWEIRDR LLAEGVCDND TVPSVSSINR IIRTKVQQPF NLPMDSCVAT KSLSPGHTLI PSSAVTPPES PQSDSLGSTY SINGLLGIAQ PGSDKRKMDD SDQDSCRLSI DSQSSSSGPR KHLRTDAFSQ HHLEPLECPF ERQHYPEAYA SPSHTKGEQG LYPLPLLNST LDDGKATLTP SNTPLGRNLS THQTYPVVAD PHSPFAIKQE TPEVSSSSST PSSLSSSAFL DLQQVGSGVP PFNAFPHAAS VYGQFTGQAL LSGREMVGPT LPGYPPHIPT SGQGSYASSA IAGMVAGSEY SGNAYGHTPY SSYSEAWRFP NSSLLSSPYY YSSTSRPSAP PTTATAFDHL

靶标信息

This gene encodes a member of the paired box family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HGNC:8622; Paired box protein Pax-8; paired domain gene 8

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基因别名: PAX8

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UniProt ID: (Human) Q06710

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Entrez Gene ID: (Human) 7849

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RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding thyroid-stimulating hormone receptor activity protein binding transcription regulatory region DNA binding

参与通路

urogenital system development branching involved in ureteric bud morphogenesis kidney development mesonephros development mesenchymal to epithelial transition involved in metanephros morphogenesis transcription, DNA-templated transcription from RNA polymerase II promoter sulfur compound metabolic process central nervous system development anatomical structure morphogenesis thyroid gland development thyroid-stimulating hormone signaling pathway pronephric field specification inner ear morphogenesis regulation of apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter pronephros development cellular response to gonadotropin stimulus otic vesicle development positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric epithelium development metanephric distal convoluted tubule development metanephric comma-shaped body morphogenesis metanephric S-shaped body morphogenesis metanephric nephron tubule formation negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis regulation of metanephric nephron tubule epithelial cell differentiation positive regulation of branching involved in ureteric bud morphogenesis negative regulation of mesenchymal cell apoptotic process involved in metanephros development negative regulation of apoptotic process involved in metanephric collecting duct development negative regulation of apoptotic process involved in metanephric nephron tubule development positive regulation of metanephric DCT cell differentiation positive regulation of thyroid hormone generation regulation of thyroid-stimulating hormone secretion