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This antibody is predicted to react with canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
MCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: alpha CP-4; Alpha-CP4; alphaCP-4 protein; LYST-interacting protein; Poly(rC)-binding protein 4; RNA binding protein MCG10
基因别名: CBP; LIP4; MCG10; PCBP4
UniProt ID: (Human) P57723
Entrez Gene ID: (Human) 57060
分子生物学功能:
RNA metabolism protein