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产品信息
PA5-49709
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Full length fusion protein of Human PDCD10
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2635162
产品详细信息
The antibody detects endogenous level of total PDCD10 protein.
靶标信息
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.
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生物信息学
蛋白别名: apoptosis-related protein 15; Cerebral cavernous malformations 3 protein; MGC1212; MGC24477; PDCD 10; Programmed cell death protein 10; TF-1 cell apoptosis-related protein 15
基因别名: CCM3; PDCD10; TFAR15
UniProt ID: (Human) Q9BUL8
Entrez Gene ID: (Human) 11235
angiogenesis
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell migration
positive regulation of stress-activated MAPK cascade
positive regulation of peptidyl-serine phosphorylation
regulation of Rho protein signal transduction
intrinsic apoptotic signaling pathway in response to hydrogen peroxide
response to hydrogen peroxide
negative regulation of apoptotic process
stress fiber assembly
positive regulation of MAP kinase activity
wound healing, spreading of cells
positive regulation of Notch signaling pathway
protein stabilization
establishment of Golgi localization
positive regulation of protein serine/threonine kinase activity
negative regulation of cell migration involved in sprouting angiogenesis
Golgi reassembly
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
