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Immunogen sequence: MQDPNADTE WNDILRKKGI LPPKESLKEL EEEAEEEQRI LQQSVVKTYE DMTLEELEDH EDEFNEEDER AIEMYRRRRL AEWKATKLKN KFGEVLEISG KDYVQEVTKA GEGLWVILHL YKQGIPLCAL INQHLSGLAR KFPDVKFIKA ISTTCIPNYP DRNLPTIFVY LEGDIKAQFI GPLVFGGMNL TRDELEWKLS ESGAIMTDLE ENPKKPIEDV LLSSVRRSVL MKRDSDSEGD (1-239 aa encoded by BC001021)
Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling. PDCL3 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. Along with the related protein PDCL2, PDCL3 interacts with the chaperonin CCT and modulates CCT-mediated actin and tubulin folding. Modulation of PDCL3 levels by MAPK phosphorylation and RhoA-dependent changes also promote cytoskeletal remodeling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: HTPHLP; IAP-associated factor VIAF1; phosducin-like 3; Phosducin-like protein 3; PhPL3; VIAF-1; Viral IAP-associated factor 1
基因别名: 1110061A19Rik; C80025; HTPHLP; PDCL3; PHLP2A; PHLP3; VIAF; VIAF1
UniProt ID: (Human) Q9H2J4, (Mouse) Q8BVF2
Entrez Gene ID: (Human) 79031, (Mouse) 68833