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产品信息
H00201626-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PDE12 (ACE87622.1, 1 a.a. approximately 575 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MERAVVRRVP SEPKLSLSFA LADGSHKNMQ RDQSEPLGRV LSRIATNALK GHAKAAAAKK SRKSRPNASG GAACSGPGPE PAVFCEPVVK LYYREEAVAE DVLNVDAWQD GAVLQIGDVK YKVERNPPAF TELQLPRYIM AGFPVCPKLS LEFGDPASSL FRWYKEAKPG AAEPEVGVPS SLSPSSPSSS WTETDVEERV YTPSNADIGL RLKLHCTPGD GQRFGHSREL ESVCVVEAGP GTCTFDHRHL YTKKVTEDAL IRTVSYNILA DTYAQTEFSR TVLYPYCAPY ALELDYRQNL IQKELTGYNA DVICLQEVDR AVFSDSLVPA LEAFGLEGVF RIKQHEGLAT FYRKSKFSLL SQHDISFYEA LESDPLHKEL LEKLVLYPSA QEKVLQRSSV LQVSVLQSTK DSSKRICVAN THLYWHPKGG YIRLIQMAVA LAHIRHVSCD LYPGIPVIFC GDFNSTPSTG MYHFVINGSI PEDHEDWASN GEEERCNMSL THFFKLKSAC GEPAYTNYVG GFHGCLDYIF IDLNALEVEQ VIPLPSHEEV TTHQALPSVS HPSDHIALVC DLKWK
靶标信息
PDE12 is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3',5'-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2',5'-phosphodiesterase 12; 2'-PDE; 2'-phosphodiesterase; Mitochondrial deadenylase
基因别名: 2'-PDE; 2-PDE; PDE12
UniProt ID: (Human) Q6L8Q7
Entrez Gene ID: (Human) 201626
