Fabgennix

PDE6 Beta Polyclonal Antibody, Biotin

产品信息

PD6B-BIOTIN

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化 (IHC)

1:50-1:250

免疫细胞化学 (ICC/IF)

1:50-1:250

酶联免疫吸附实验 (ELISA)

1:10,000

免疫沉淀 (IP)

1:50-1:250

免疫电镜技术 (IM)

1:50-1:200

产品规格

种属反应

Bovine, Human, Mouse, Pig, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic cyclic petide common to all PDE6 Beta variants

偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways. Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates. PDE6 is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. There are five different subunits consisting of rod and cone specific catalytic subunits: alpha' (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family). The catalytic core of the PDE6 system is comprised of alpha'/alpha' homodimers in the cone and alpha/beta heterodimers in the rod. The C-terminus of both the catalytic and inhibitory subunits is modified by methylation, myristyolation and prenylation which have been shown to be critical for proper complex assembly and membrane association.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: cGMP-phosphodiesterase beta-subunit; GMP-PDE beta; phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide; phosphodiesterase 6B, cGMP-specific, rod, beta; phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant); phosphodiesterase, cGMP, rod receptor, beta polypeptide; phosphodiesterase, cyclic GMP ( rod receptor), beta polypeptide; retinal degeneration 1; rod cGMP phosphodiesterase beta-subunit (EC 3.1.4.17); rod cGMP-phosphodiesterase beta-subunit; Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

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基因别名: CSNB3; CSNBAD2; Mpb; PDE6B; PDEB; r; rd; rd-1; rd1; rd10; RP40

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UniProt ID: (Bovine) P23439, (Human) P35913, (Mouse) P23440