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产品信息
PA5-82379
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human PDGFC. Recombinant protein control fragment (Product #RP-89554).
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Anitgen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2789538
产品详细信息
Immunogen sequence: LDLLNNAITA FSTLEDLIRY LEPERWQLDL EDLYRPTWQL LGKAFVFGRK SRVVDLNLLT EEVLQLRPKT GVRGLHKSLT DVA
靶标信息
Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cellcell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C76851; Fallotein; MGC102297; PDGF-C; Platelet-derived growth factor C; SCDGF; secretory growth factor-like protein; Spinal cord-derived growth factor; VEGF-E
基因别名: FALLOTEIN; PDGFC; SCDGF; UNQ174/PRO200
UniProt ID: (Human) Q9NRA1
Entrez Gene ID: (Human) 56034
activation of transmembrane receptor protein tyrosine kinase activity
central nervous system development
blood coagulation
embryo development
organ morphogenesis
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of cell migration
positive regulation of protein autophosphorylation
positive regulation of MAP kinase activity
positive regulation of DNA replication
platelet-derived growth factor receptor signaling pathway
positive regulation of fibroblast proliferation
digestive tract development
regulation of peptidyl-tyrosine phosphorylation
positive regulation of cell division
bone development
positive regulation of ERK1 and ERK2 cascade
cellular response to amino acid stimulus
