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PDK2 Antibody (MA5-35568) in IHC (P)
Immunohistochemistry analysis of PDK2 in paraffin-embedded human colon. Samples were incubated with PDK2 Monoclonal antibody (Product # MA5-35568) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
MA5-35568
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1113
抗原
A synthetic peptide corresponding to a sequence within amino acids 308-407 of human PDK2 (Q15119)
偶联物
形式
Liquid
浓度
0.38 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849468
产品详细信息
Immunogen sequence: YSTAPTPQPG TGGTPLAGFG YGLPISRLYA KYFQGDLQLF SMEGFGTDAV IYLKALSTDS VERLPVYNKS AWRHYQTIQE AGDWCVPSTE PKNTSTYRVS
靶标信息
PDK2 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial; PDH kinase 2; PDK P45; pyruvate dehydrogenase; pyruvate dehydrogenase 2; pyruvate dehydrogenase kinase 2 subunit p45 (PDK2); Pyruvate dehydrogenase kinase isoform 2; pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase kinase, isozyme 2; pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial
基因别名: PDHK2; PDK2; PDKII
UniProt ID: (Human) Q15119, (Rat) Q64536, (Mouse) Q9JK42
Entrez Gene ID: (Human) 5164, (Rat) 81530, (Mouse) 18604
protein kinase activity
pyruvate dehydrogenase (acetyl-transferring) kinase activity
ATP binding
protein homodimerization activity
protein serine/threonine kinase activity
protein complex binding
protein heterodimerization activity
nucleotide binding
protein binding
kinase activity
transferase activity
non-receptor serine/threonine protein kinase
glucose metabolic process
regulation of gluconeogenesis
protein phosphorylation
regulation of pH
insulin receptor signaling pathway
regulation of acetyl-CoA biosynthetic process from pyruvate
regulation of cellular ketone metabolic process
regulation of glucose metabolic process
cellular response to nutrient
cellular response to reactive oxygen species
glucose homeostasis
intrinsic apoptotic signaling pathway by p53 class mediator
peptidyl-serine phosphorylation
carbohydrate metabolic process
phosphorylation
