Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 4
PDX1 Antibody (PA5-106922) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-PDX1 (Thr11) in rat lung tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-PDX1 (Thr11) polyclonal antibody (Product # PA5-106922) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-106922
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PDX1(Accession P52945), corresponding to amino acid residues M38-A88.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854586
产品详细信息
Antibody detects endogenous levels of total PDX1.
靶标信息
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: DLDBP; Glucose-sensitive factor; GSF; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; insulin promotor factor 1; Insulin upstream factor 1; IPF-1; Islet/duodenum homeobox 1; Islet/duodenum homeobox-1; IUF-1; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox gene 1; pancreatic-duodenal homeobox factor 1; PDHX; PDX-1; somatostatin transactivating factor 1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1
基因别名: GSF; IDX-1; Idx1; IPF-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; PDX1; STF-1; STF1
UniProt ID: (Human) P52945, (Rat) P52947, (Mouse) P52946
Entrez Gene ID: (Human) 3651, (Rat) 29535, (Mouse) 18609
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor binding
protein complex binding
protein heterodimerization activity
DNA binding
protein binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
liver development
type B pancreatic cell differentiation
glucose metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
smoothened signaling pathway
nitric oxide mediated signal transduction
central nervous system development
positive regulation of cell proliferation
negative regulation of cell proliferation
response to wounding
response to glucose
response to iron(II) ion
response to chlorate
organ senescence
positive regulation of cell death
response to organic cyclic compound
morphogenesis of embryonic epithelium
insulin secretion
cell differentiation
pancreas development
exocrine pancreas development
endocrine pancreas development
organ regeneration
response to nutrient levels
positive regulation of insulin secretion
response to vitamin
response to lipid
response to cytokine
response to nicotine
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of cell proliferation
response to drug
glucose homeostasis
response to leucine
response to alkaloid
positive regulation of DNA binding
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
stem cell differentiation
response to glucocorticoid
detection of glucose
transdifferentiation
response to fatty acid
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of type B pancreatic cell apoptotic process
multicellular organism development
regulation of gene expression
generation of precursor metabolites and energy
organ morphogenesis
