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Positive Samples: HeLa, Mouse lung, Mouse kidney, Rat lung
Immunogen sequence: GRRGAKDEAL GEESGERWSP EFHLQRKLAD SSHSEQQDRN RVSEELIMVV QEMKKYFPSE RRNKPSTLDA LNYALRCVHS VQANSEFFQI L
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cell growth-inhibiting gene 13 protein; Circadian clock protein PERIOD 3; hPER3; mPER3; period circadian protein 3; Period circadian protein homolog 3; period homolog 3; rPER3
基因别名: 2810049O06Rik; FASPS3; GIG13; mPer3; PER3; period3; rper3
UniProt ID: (Human) P56645, (Mouse) O70361, (Rat) Q8CJE2
Entrez Gene ID: (Human) 8863, (Mouse) 18628, (Rat) 78962
分子生物学功能:
transcription cofactor
gene-specific transcriptional regulator