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PERK Antibody (MA5-24754) in WB
Western blot analysis of EIF2AK3 in 1) A549, 2) PC-12, 3) mouse brain, 4) mouse liver lysate using 20 µg of sample per lane. Proteins on the membrane were blocked with 5% NFDM in TBST. The sample was probed with EIF2AK3 monoclonal antibody (Product # MA5-24754) with a dilution of 1:250-1:1000, and goat Anti-mouse IgG, (H+L), Peroxidase conjugated secondary antibody with a dilution of 1:10,000.
产品信息
MA5-24754
产品规格
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1385CT582.4.39
抗原
synthetic peptide between 530-850 amino acids from human PERK
偶联物
形式
Liquid
浓度
0.5 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2717229
靶标信息
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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