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Immunogen sequence: LQSSDHGQTS SLWWKCSQEG GGSGSYEEGC QSLMEYAW
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 1110017A08Rik; HGNC:17637; KCP-1; keratinocyte associated protein 1; Keratinocyte-associated protein 1; keratinocytes associated protein 1; p53 apoptosis effector related to PMP-22; p53 apoptosis effector related to PMP22; P53-induced protein PIGPC1; RP3-496H19.1; Transmembrane protein THW
基因别名: dJ496H19.1; KCP1; KRTCAP1; PERP; PIGPC1; THW
UniProt ID: (Human) Q96FX8
Entrez Gene ID: (Human) 64065