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产品信息
MA5-38148
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC2094
抗原
A synthetic peptide corresponding to a sequence within amino acids 94-193 of human PERP (Q96FX8)
偶联物
形式
Liquid
浓度
1.2 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2898066
产品详细信息
Positive Samples: HepG2, BxPC-3, A-431, Mouse liver, Mouse kidney, Rat lung, Rat liver
Immunogen sequence: LSFFALCGPQ MLVFLRVIGG LLALAAVFQI ISLVIYPVKY TQTFTLHANP AVTYIYNWAY GFGWAATIIL IGCAFFFCCL PNYEDDLLGN AKPRYFYTSA
靶标信息
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 1110017A08Rik; HGNC:17637; KCP-1; keratinocyte associated protein 1; Keratinocyte-associated protein 1; keratinocytes associated protein 1; p53 apoptosis effector related to PMP-22; p53 apoptosis effector related to PMP22; p53 apoptosis-associated target; P53-induced protein PIGPC1; RP3-496H19.1; Transmembrane protein THW
基因别名: 1110017A08Rik; dJ496H19.1; KCP1; KRTCAP1; PERP; PIGPC1; THW
UniProt ID: (Human) Q96FX8, (Mouse) Q9JK95
Entrez Gene ID: (Human) 64065, (Mouse) 64058, (Rat) 292949
desmosome organization
Notch signaling pathway
heterotypic cell-cell adhesion
regulation of apoptotic process
positive regulation of proteolysis
intrinsic apoptotic signaling pathway by p53 class mediator
amelogenesis
activation of cysteine-type endopeptidase activity
cell-cell adhesion
apoptotic process
cell adhesion
