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Immunogen sequence: DGRVYEGVG WNIQGLHTQG YNNISLGIAF FGNKIGSSPS PAALSAAEGL ISYAIQKGHL SPRYIQPLLL KEETCLDPQH PVMPRKVCPN IIKRSAWEAR ETHCPKMNLP AKYVIIIHTA GTSCTVSTDC QTVVRNIQSF HMDTRNFCDI GYHF (92-244 aa encoded by BC069741)
Primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1, 2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-I beta) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4). PGRP-1a mRNA is highly expressed in esophagus, tonsils and thymus and to lesser extent in the stomach, rectum, and brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MGC149197; Peptidoglycan recognition protein 3; peptidoglycan recognition protein I alpha; Peptidoglycan recognition protein I-alpha; Peptidoglycan recognition protein intermediate alpha; PGLYRPIalpha; PGRP-I-alpha
基因别名: Gm420; PGLYRP3; PGLYRPIalpha; PGRP-Ialpha; PGRPIA
UniProt ID: (Human) Q96LB9, (Mouse) A1A547
Entrez Gene ID: (Human) 114771, (Mouse) 242100, (Rat) 499658