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PI4K2A Antibody (PA5-15275) in ICC/IF
Immunocytochemistry analysis of PI4K2A in HeLa cells. Samples were incubated with PI4K2A polyclonal antibody (Product # PA5-15275) using a dilution of 0.025 mg/mL followed by Alexa-Fluor-546-conjugated donkey anti-rabbit lgG (H+L). Negative control of Hela cells without Alexa-Fluor-546-conjugated donkey anti-rabbit lgG (H+L). Alexa-Fluor-546 emits orange fluorescence.
产品信息
PA5-15275
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PI4K2A (PI4K II)
偶联物
Unconjugated
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2163898
靶标信息
PI4K2A (PI4K2 alpha) lipid kinase or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4K2A phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4K2A is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4K2A generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes. PI4K2A is also required for Wnt to regulate LRP6 phosphorylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: phosphatidylinositol 4-kinase; Phosphatidylinositol 4-kinase type 2-alpha; phosphatidylinositol 4-kinase type II (PI4KII); Phosphatidylinositol 4-kinase type II-alpha
基因别名: Pi4k2; PI4K2A; PI4KII; PIK42A
UniProt ID: (Human) Q9BTU6, (Mouse) Q2TBE6
Entrez Gene ID: (Human) 55361, (Mouse) 84095
